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Open access

Chronic mucocutaneous candidiasis: a spectrum of genetic disorders

Publication: LymphoSign Journal
7 September 2017

Abstract

Chronic mucocutaneous candidiasis (CMCC) encompasses a heterogeneous group of syndromes associated with persistent or recurrent Candida infections of the skin, nails, and mucous membranes. While chronic candidiasis can present by itself or as part of a complex, including endocrinopathy, autoimmune manifestations, bone marrow failure and neoplastic diseases, it is often regarded as a warning sign for immunodeficiency. Here, we review the processes involved in host-microbial recognition of Candida and highlight underlying genetic causes of CMCC—including those that are monogenic (such as mutations in AIRE and STAT1) as well as polymorphisms that increase susceptibility to candidal infection.
Statement of novelty: This review provides an overview of the pathophysiology of Candida fungal infection as well as genetic defects that have been identified to cause CMCC.

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Published In

cover image LymphoSign Journal
LymphoSign Journal
Volume 4Number 3September 2017
Pages: 87 - 99

History

Received: 4 August 2017
Accepted: 5 September 2017
Accepted manuscript online: 7 September 2017

Authors

Affiliations

Pediatrics Department A, Saban Pediatric Medical Center, Soroka University Medical Center, and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
The Primary Immunodeficiency Research Laboratory, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Cited by

1. Chronic mucocutaneous candidiasis associated with a novel frameshift mutation in IL-17 receptor alpha
2. Abstracts from the Immunodeficiency Canada—6th SCID Symposium, Halifax, NS, 13 September 2018

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