Eosinophilic esophagitis: a review

Aceves S.S., Newbury R.O., Dohil M.A., Bastian J.F., and Dohil R. 2009. A symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammation. Ann. Allergy Asthma Immunol. 103:401–406.

Aceves S.S., Newbury R.O., Dohil R., Schwimmer J., and Bastian J.F. 2007. Distinguishing eosinophilic esophagitis in pediatric patients: Clinical, endoscopic, and histologic features of an emerging disorder. J. Clin. Gastroenterol. 41:252–256.

Akhondi H. 2017. Diagnostic approaches and treatment of eosinophilic esophagitis. A review article. Ann. Med. Surg. 20:69–73.

Alexander E.S., Martin L.J., Collins M.H., Kottyan L.C., Sucharew H., He H., Mukkada V.A., Succop P.A., Abonia J.P., Foote H., Eby M.D., Grotjan T.M., Greenler A.J., Dellon E.S., Demain J.G., Furuta G.T., Gurian L.E., Harley J.B., Hopp R.J., Kagalwalla A., Kaul A., Nadeau K.C., Noel R.J., Putnam P.E., von Tiehl K.F., and Rothenberg M.E. 2014. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J. Allergy Clin. Immunol. 134(5):1084–1092.e1.

Alexander J.A., Jung K.W., Arora A.S., Enders F., Katzka D.A., Kephardt G.M., Kita H., Kryzer L.A., Romero Y., Smyrk T.C., and Talley N.J. 2012. Swallowed fluticasone improves histologic but not symptomatic response of adults with eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 10:742–749.e1.

Alsalamah M., Makhajia M., Somers G., Marcon M., Hummel D., and Upton J. 2016. Corrigendum: Anaphylaxis to milk after elimination diet for eosinophilic gastrointestinal disease. Am. J. Gastroenterol. 111(7):1078.

Arias A., González-Cervera J., Tenias J.M., and Lucendo A.J. 2014. Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: A systematic review and meta-analysis. Gastroenterology. 146:1639–1648.

Assa’ad A.H., Gupta S.K., Collins M.H., Thomson M., Heath A.T., Smith D.A., Perschy T.L., Jurgensen C.H., Ortega H.G., and Aceves S.S. 2011. An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis. Gastroenterology. 141(5):1593–1604.

Attwood S.E., Smyrk T.C., Demeester T.R., and Jones J.B. 1993. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome. Dig. Dis. Sci. 38(1):109–116.

Binkovitz L.A., Lorenz E.A., Di Lorenzo C., and Kahwash S. 2010. Pediatric eosinophilic esophagitis: Radiologic findings with pathologic correlation. Pediatr. Radiol. 40:714–719.

Blanchard C., Mingler M.K., McBride M., Putnam P.E., Collins M.H., Chang G., Stringer K., Abonia J.P., Molkentin J.D., and Rothenberg M.E. 2008. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol. 1:289–296.

Blanchard C., Wang N., Stringer K.F., Mishra A., Fulkerson P.C., Abonia J.P., Jameson S.C., Kirby C., Konikoff M.R., Collins M.H., Cohen M.B., Akers R., Hogan S.P., Assa’ad A.H., Putnam P.E., Aronow B.J., and Rothenberg M.E. 2006. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J. Clin. Invest. 116:536–547.

Boguniewicz M. 2017. Biologic therapy for atopic dermatitis: Moving beyond the practice parameter and guidelines. J. Allergy Clin. Immunol. Pract. 5(6):1477–1487.

Bonis, P.A., and Furuta, G.T. 2017. Clinical manifestations and diagnosis of eosinophilic esophagitis. Edited by S. Grover. UpToDate, Waltham, MA, USA.

Butz B.K., Wen T., Gleich G.J., Furuta G.T., Spergel J., King E., Kramer R.E., Collins M.H., Stucke E., Mangeot C., Jackson W.D., O’Gorman M., Abonia J.P., Pentiuk S., Putnam P.E., and Rothenberg M.E. 2014. Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology. 147:324–333.e5.

Clayton F., Fang J.C., Gleich G.J., Lucendo A.J., Olalla J.M., Vinson L.A., Lowichik A., Chen X., Emerson L., Cox K., O’Gorman M.A., and Peterson K.A. 2014. Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE. Gastroenterology. 147:602–609.

Dellon E.S. 2014. Epidemiology of eosinophilic esophagitis. Gastroenterol. Clin. North Am. 43(2):201–218.

Dellon E.S., Gibbs W.B., Fritchie K.J., Rubinas T.C., Wilson L.A., Woosley J.T., and Shaheen N.J. 2009. Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease. Clin. Gastroenterol. Hepatol. 7:1305–1313.

Dellon E.S., Gonsalves N., Hirano I., Furuta G.T., Liacouras C.A., and Katzka D.A. 2013a. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EOE). Am. J. Gastroenterol. 108(5):679–692.

Dellon E.S., Jensen E.T., Martin C.F., Shaheen N.J., and Kappelman M.D. 2014. Prevalence of eosinophilic esophagitis in the United States. Clin. Gastroenterol. Hepatol. 12(4):589–596.e1.

Dellon E.S, Peery A.F., Shaheen N.J., Morgan D.R., Hurrell J.M., Lash R.H., and Genta R.M. 2011. Inverse association of esophageal eosinophilia with Helicobacter pylori based on analysis of a US pathology database. Gastroenterology. 141(5):1586–1592.

Dellon E.S., Speck O., Woodward K., Gebhart J.H., Madanick R.D., Levinson S., Fritchie K.J., Woosley J.T., and Shaheen N.J. 2013b. Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: A prospective cohort study. Am. J. Gastroenterol. 108(12):1854–1860.

Erwin E.A., James H.R., Gutekunst H.M., Russo J.M., Kelleher K.J., and Platts-Mills T.A. 2010. Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis. Ann. Allergy Asthma Immunol. 104:496–502.

Franciosi J.P., Tam V., Liacouras C.A., and Spergel J.M. 2009. A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 7(4):415–419.

Furuta G.T., Kagalwalla A.F., Lee J.J., Alumkal P., Maybruck B.T., Fillon S., Masterson J.C., Ochkur S., Protheroe C., Moore W., Pan Z., Amsden K., Robinson Z., Capocelli K., Mukkada V., Atkins D., Fleischer D., Hosford L., Kwatia M.A., Schroeder S., Kelly C., Lovell M., Melin-Aldana H., and Ackerman S.J. 2013. The oesophageal string test: A novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis. Gut. 62(10):1395–1405.

Giriens B., Yan P., Safroneeva E., Zwahlen M., Reinhard A., Nydegger A., Vavricka S., Sempoux C., Straumann A., and Schoepfer A.M. 2015. Escalating incidence of eosinophilic esophagitis in Canton of Vaud, Switzerland, 1993–2013: A population-based study. Allergy. 70(12):1633–1639.

Gudbjartsson D.F., Bjornsdottir U.S., Halapi E., Helgadottir A., Sulem P., Jonsdottir G.M., Thorleifsson G., Helgadottir H., Steinthorsdottir V., Stefansson H., Williams C., Hui J., Beilby J., Warrington N.M., James A., Palmer L.J., Koppelman G.H., Heinzmann A., Krueger M., Boezen H.M., Wheatley A., Altmuller J., Shin H.D., Uh S.T., Cheong H.S., Jonsdottir B., Gislason D., Park C.S., Rasmussen L.M., Porsbjerg C., Hansen J.W., Backer V., Werge T., Janson C., Jönsson U.B., Ng M.C., Chan J., So W.Y., Ma R., Shah S.H., Granger C.B., Quyyumi A.A., Levey A.I., Vaccarino V., Reilly M.P., Rader D.J., Williams M.J., van Rij A.M., Jones G.T., Trabetti E., Malerba G., Pignatti P.F., Boner A., Pescollderungg L., Girelli D., Olivieri O., Martinelli N., Ludviksson B.R., Ludviksdottir D., Eyjolfsson G.I., Arnar D., Thorgeirsson G., Deichmann K., Thompson P.J., Wjst M., Hall I.P., Postma D.S., Gislason T., Gulcher J., Kong A., Jonsdottir I., Thorsteinsdottir U., and Stefansson K. 2009. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat. Genet. 41:342–347.

Gupta S.K., Vitanza J.M., and Collins M.H. 2015. Efficacy and safety of oral budesonide suspension in pediatric patients with eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 13:66–76.e3.

Harris J.K., Fang R., Wagner B.D., Choe H.N., Kelly C.J., Schroeder S., Moore W., Stevens M.J., Yeckes A., Amsden K., Kagalwalla A.F., Zalewski A., Hirano I., Gonsalves N., Henry L.N., Masterson J.C., Robertson C.E., Leung D.Y., Pace N.R., Ackerman S.J., Furuta G.T., and Fillon S.A. 2015. Esophageal microbiome in eosinophilic esophagitis. PLoS ONE. 10(5):e0128346.

Helou E.F., Simonson J., and Arora A.S. 2008. 3-yr-follow-up of topical corticosteroid treatment for eosinophilic esophagitis in adults. Am. J. Gastroenterol. 103(9):2194–2199.

Henderson C.J., Abonia J.P., King E.C., Putnam P.E., Collins M.H., Franciosi J.P., and Rothenberg M.E. 2012. Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis. J. Allergy Clin. Immunol. 129:1570–1578.

Hill D.A., Shuker M., Cianferoni A., Wong T., Ruchelli E., Spergel J.M., and Brown-Whitehorn T.F. 2015. The development of IgE-mediated immediate hypersensitivity after the diagnosis of eosinophilic esophagitis to the same food. J. Allergy Clin. Immunol. Pract. 3(1):123–124.

Hruz P., Straumann A., Bussmann C., Heer P., Simon H.U., Zwahlen M., Beglinger C., and Schoepfer A.M.and Swiss EoE study group. 2011. Escalating incidence of eosinophilic esophagitis: A 20-year prospective, population-based study in Olten County, Switzerland. J. Allergy Clin. Immunol. 128(6):1349–1350.e5.

Hurrell J.M., Genta R.M., and Dellon E.S. 2012. Prevalence of esophageal eosinophilia varies by climate zone in the United States. Am. J. Gastroenterol. 107(5):698–706.

Ishihara S., Kinoshita Y., and Schoepfer A. 2016. Eosinophilic esophagitis, eosinophilic gastroenteritis, and eosinophilic colitis: Common mechanisms and differences between East and West. Inflamm. Intest. Dis. 1:63–69.

Jensen E.T., Hoffman K., Shaheen N.J., Genta R.M., and Dellon E.S. 2014. Esophageal eosinophilia is increased in rural areas with low population density: Results from a national pathology database. Am. J. Gastroenterol. 109(5):668–675.

Jensen E.T., Kappelman M.D., Kim H.P., Ringel-Kulka T., and Dellon E.S. 2013. Early life exposures as risk factors for pediatric eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. 57(1):67–71.

Kagalwalla A.F., Amsden K., Shah A., Ritz S., Manuel-Rubio M., Dunne K., Nelson S.P., Wershil B.K., and Melin-Aldana H. 2012. Cow’s milk elimination: A novel dietary approach to treat eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. 55:711–716.

Kagalwalla A.F., Sentongo T.A., Ritz S., Hess T., Nelson S.P., Emerick K.M., Melin-Aldana H., and Li B.U. 2006. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 4:1097–1102.

Kagalwalla A.F., Shah A., Li B.U., Sentongo T.A., Ritz S., Manuel-Rubio M., Jacques K., Wang D., Melin-Aldana H., and Nelson S.P. 2011. Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J. Pediatr. Gastroenterol. Nutr. 53(2):145–149.

Kagalwalla A.F., Wechsler J.B., Amsden K., Schwartz S., Makhija M., Olive A., Davis C.M., Manuel-Rubio M., Marcus S., Shaykin R., Sulkowski M., Johnson K., Ross J.N., Riffle M.E., Groetch M., Melin-Aldana H., Schady D., Palac H., Kim K.A., Wershil B.K., Collins M.H., and Chehade M. 2017. Efficacy of a 4-food elimination diet for children with eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 15(11):1698–1707.e7.

Kapel R.C., Miller J.K., Torres C., Aksoy S., Lash R., and Katzka D.A. 2008. Eosinophilic esophagitis: A prevalent disease in the United States that affects all age groups. Gastroenterology. 134:1316–1321.

Katzka D.A., Geno D.M., Ravi A., Smyrk T.C., Lao-Sirieix P., Miremadi A., Debiram I., O’Donovan M., Kita H., Kephart G.M., Kryzer L.A., Camilleri M., Alexander J.A., and Fitzgerald R.C. 2015. Accuracy, safety, and tolerability of tissue collection by Cytosponge vs endoscopy for evaluation of eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 13(1):77–83.e2.

Kedika R.R., Souza R.F., and Spechler S.J. 2009. Potential anti-inflammatory effects of proton pump inhibitors: A review and discussion of the clinical implications. Dig. Dis. Sci. 54:2312–2317.

Konikoff M.R., Noel R.J., Blanchard C., Kirby C., Jameson S.C., Buckmeier B.K., Akers R., Cohen M.B., Collins M.H., Assa’ad A.H., Aceves S.S., Putnam P.E., and Rothenberg M.E. 2006. A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology. 131:1381–1391.

Kruszewski P.G., Russo J.M., Franciosis J.P., Varni J.W., Platts-Mills T.A., and Erwin E.A. 2016. Prospective, comparative effectiveness trial of cow’s milk elimination and swallowed fluticasone for pediatric eosinophilic esophagitis. Dis. Esophagus. 29:377–384.

Landres R.T., Kuster G.G., and Strum W.B. 1978. Eosinophilic esophagitis in a patient with vigorous achalasia. Gastroenterology. 74(6):1298–1301.

Leung J., Virk Hundal N., Katz A.J., Shreffler W.G., Yuan Q., Butterworth C.A., and Hesterberg P.E. 2013. Tolerance of baked milk in patients with cow’s milk-mediated eosinophilic esophagitis. J. Allergy Clin. Immunol. 132(5):1215–1216.e1.

Liacouras C.A., Furuta G.T., Hirano I., Atkins D., Attwood S.E., Bonis P.A., Burks A.W., Chehade M., Collins M.H., Dellon E.S., Dohil R., Falk G.W., Gonsalves N., Gupta S.K., Katzka D.A., Lucendo A.J., Markowitz J.E., Noel R.J., Odze R.D., Putnam P.E., Richter J.E., Romero Y., Ruchelli E., Sampson H.A., Schoepfer A., Shaheen N.J., Sicherer S.H., Spechler S., Spergel J.M., Straumann A., Wershil B.K., Rothenberg M.E., and Aceves S.S. 2011. Eosinophilic esophagitis: Updated consensus recommendations for children and adults. J. Allergy Clin. Immunol. 128(1):3–20.e6.

Litosh VA, Rochman M., Rymer J.K., Porollo A., Kottyan L.C., and Rothenberg M.E. 2017. Calpain-14 and its association with eosinophilic esophagitis. J. Allergy Clin. Immunol. 139(6):1762–1771.e7.

Loizou D., Enav B., Komlodi-Pasztor E., Hider P., Kim-Chang J., Noonan L., Taber T., Kaushal S., Limgala R., Brown M., Gupta R., Balba N., Goker-Alpan O., Khojah A., and Alpan O. 2015. A pilot study of omalizumab in eosinophilic esophagitis. PLoS ONE. 10:e0113483.

Mackenzie S.H., Go M., Chadwick B., Thomas K., Fang J., Kuwada S., Lamphier S., Hilden K., and Peterson K. 2008. Eosinophilic oesophagitis in patients presenting with dysphagia—A prospective analysis. Aliment. Pharmacol. Ther. 28(9):1140–1146.

Markowitz J.E., Spergel J.M., Ruchelli E., and Liacouras C.A. 2003. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am. J. Gastroenterol. 98:777–782.

Masuoka M., Shirasishi H., Ohta S., Suzuki S., Arima K., Aoki S., Toda S., Inagaki N., Kurihara Y., Hayashida S., Takeuchi S., Koike K., Ono J., Noshiro H., Furue M., Conway S.J., Narisawa Y., and Izuhara K. 2012. Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J. Clin. Invest. 122:2590–2600.

Merwat S.N. and Spechler S.J. 2009. Might the use of acid-suppressive medications predispose to the development of eosinophilic esophagitis? Am. J. Gastroenterol. 104(8):1897–1902.

Miehlke S., Hruz P., Vieth M., Bussmann C., von Arnim U., Bajbouj M., Schlag C., Madisch A., Fibbe C., Wittenburg H., Allescher H.D., Reinshagen M., Schubert S., Tack J., Müller M., Krummenerl P., Arts J., Mueller R., Dilger K., Greinwald R., and Straumann A. 2016. A randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis. Gut. 65:390–399.

Mishra A., Hogan S.P., Brandt E.B., and Rothenberg M.E. 2001. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J. Clin. Invest. 107:83–90.

Moawad F.J., Cheatham J.G., and DeZee K.J. 2013. Meta-analysis: The safety and efficacy of dilation in eosinophilic oesophagitis. Aliment. Pharmacol. Ther. 38:713–720.

Moawad F.J., Cheng E., Schoepfer A., Al-Haddad S., Bellizzi A.M., Dawson H., El-Zimaity H., Guindi M., Penagini R., Safrooneva E., and Chehade M. 2016. Eosinophilic esophagitis: Current perspectives from diagnosis to management. Ann. N.Y. Acad. Sci. 1380:204–217.

Molina-Infante J. and Katzka D.A. 2014. Proton-pump inhibitor-responsive esophageal eosinophilia. Curr. Opin. Gastroenterol. 30(4):428–433.

Molina-Infante J., Ferrando-Lamana L., Ripoll C., Hernandez-Alonso M., Mateos J.M., Fernandez-Bermejo M., Dueñas C., Fernandez-Gonzalez N., Quintana E.M., and Gonzalez-Nuñez M.A. 2011. Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults. Clin. Gastroenterol. Hepatol. 9:110–117.

Mukkada V.A., Haas A., Maune N.C., Capocelli K.E., Henry M., Gilman N., Petersburg S., Moore W., Lovell M.A., Fleischer D.M., Furuta G.T., and Atkins D. 2010. Feeding dysfunction in children with eosinophilic gastrointestinal diseases. Pediatrics. 126(3):e672–e677.

Mullin J.M., Valenzano M.C., Whitby M., Lurie D., Schmidt J.D., Jain V., Tully O., Kearney K., Lazowick D., Mercogliano G., and Thornton J.J. 2008. Esomeprazole induces upper gastrointestinal tract transmucosal permeability increase. Aliment. Pharmacol. Ther. 28(11–12):1317–1325.

Noel R.J., Putnam P.E., and Rothenberg M.E. 2004. Eosinophilic esophagitis. N. Engl. J. Med. 351(9):940–941.

Okada H., Kuhn C., Feillet H., and Bach J.F. 2010. The ‘hygiene hypothesis’ for autoimmune and allergic diseases: An update. Clin. Exp. Immunol. 160(1):1–9.

O’Regan G.M., Sandilands A., McLean W.H., and Irvine A.D. 2008. Filaggrin in atopic dermatitis. J. Allergy Clin. Immunol. 122:689–693.

O’Shea, K.M., Aceves, S.S., Dellon, E.S., Gupta, S.K., Spergel, J.M., Furuta, G.T., and Rothenberg, M.E. 2017. Pathophysiology of eosinophilic esophagitis. Gastroenterology.

Otani I.M., Anilkumar A.A., Newbury R.O., Bhagat M., Beppu L.Y., Dohil R., Broide D.H., and Aceves S.S. 2013. Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J. Allergy Clin. Immunol. 131:1576–1582.e2.

Pentiuk S., Putnam P.E., Collins M.H., and Rothenberg M.E. 2009. Dissociation between symptoms and histological severity in pediatric eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. 48:152–160.

Peterson K.A., Byrne K.R., Vinson L.A., Ying J., Boynton K.K., Fang J.C., Gleich G.J., Adler D.G., and Clayton F. 2013. Elemental diet induces histologic response in adult eosinophilic esophagitis. Am. J. Gastroenterol. 108:759–766.

Philpott H., Nandurkar S., Royce S.G., Thien F., and Gibson P.R. 2016. Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. A comprehensive prospective study using five modalities. Aliment. Pharmacol. Ther. 44(3):223–233.

Prasad G.A., Alexander J.A., Schleck C.D., Zinsmeister A.R., Smyrk T.C., Elias R.M., Locke G.R. III, and Talley N.J. 2009. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin. Gastroenterol. Hepatol. 7(10):1055–1061.

Prasad G.A., Talley N.J., Romero Y., Arora A.S., Kryzer L.A., Smyrk T.C., and Alexander J.A. 2007. Prevalence and predictive factors of eosinophilic esophagitis in patients presenting with dysphagia: A prospective study. Am. J. Gastroenterol. 102(12):2627–2632.

Radano M.C., Yan Q., Katz A., Fleming J.T., Kubala S., Shreffler W., and Keet C.A. 2014. Cesarean section and antibiotic use found to be associated with eosinophilic esophagitis. J. Allergy Clin. Immunol. Pract. 2:475–477.e1.

Rayapudi M., Mavi P., Zhu X., Pandey A.K., Abonia J.P., Rothenberg M.E., and Mishra A. 2010. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J. Leukoc. Biol. 88:337–346.

Ricker J., McNear S., Cassidy T., Plott E., Arnold H., Kendall B., and Franklin K. 2011. Routine screening for eosinophilic esophagitis in patients presenting with dysphagia. Therap. Adv. Gastroenterol. 4(1):27–35.

Rochman M., Travers J., Miracle C.E., Bedard M.C., Wen T., Azouz N.P., Caldwell J.M., Kc K., Sherrill J.D., Davis B.P., Rymer J.K., Kaufman K.M., Aronow B.J., and Rothenberg M.E. 2017. Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis. J. Allergy Clin. Immunol. 140(3):738–749.e3.

Rothenberg M.E., Spergel J.M., Sherrill J.D., Annaiah K., Martin L.J., Cianferoni A., Gober L., Kim C., Glessner J., Frackelton E., Thomas K., Blanchard C., Liacouras C., Verma R., Aceves S., Collins M.H., Brown-Whitehorn T., Putnam P.E., Franciosi J.P., Chiavacci R.M., Grant S.F., Abonia J.P., Sleiman P.M., and Hakonarson H. 2010. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat. Genet. 42(4):289–291.

Rothenberg M.E., Wen T., Greenberg A., Alpan O., Enav B., Hirano I., Nadeau K., Kaiser S., Peters T., Perez A., Jones I., Arm J.P., Strieter R.M., Sabo R., and Gunawardena K.A. 2015. Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J. Allergy Clin. Immunol. 135:500–507.

Roy-Ghanta S., Larosa D.F., and Katzka D.A. 2008. Atopic characteristics of adult patients with eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 6:531–535.

Safroneeva E., Straumann A., Coslovsky M., Zwahlen M., Kuehni C.E., Panczak R., Haas N.A., Alexander J.A., Dellon E.S., Gonsalves N., Hirano I., Leung J., Bussmann C., Collins M.H., Newbury R.O., De Petris G., Smyrk T.C., Woosley J.T., Yan P., Yang G.Y., Romero Y., Katzka D.A., Furuta G.T., Gupta S.K., Aceves S.S., Chehade M., Spergel J.M., and Schoepfer A.M.and International Eosinophilic Esophagitis Activity Index Study Group. 2016. Symptoms have modest accuracy in detecting endoscopic and histologic remission in adults with eosinophilic esophagitis. Gastroenterology. 150:581–590.e4.

Shah A., Kagalwalla A.F., Gonsalves N., Melin-Aldana H., Li B.U., and Hirano I. 2009. Histopathologic variability in children with eosinophilic esophagitis. Am. J. Gastroenterol. 104:716–721.

Sherrill J.D., Kc K., Wu D., Djukic Z., Caldwell J.M., Stucke E.M., Kemme K.A., Costello M.S., Mingler M.K., Blanchard C., Collins M.H., Abonia J.P., Putnam P.E., Dellon E.S., Orlando R.C., Hogan S.P., and Rothenberg M.E. 2014. Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. Mucosal Immunol. 7:718–729.

Soller L., Mill C., Avinashi V., Teohm T., and Chan E.S. 2017. Development of anaphylactic cow’s milk allergy following cow’s milk elimination for eosinophilic esophagitis in a teenager. J. Allergy Clin. Immunol. Pract. 5(5):1413–1414.

Sonnenberg A., Dellon E.S., Turner K.O., and Genta R.M. 2017. The influence of Helicobacter pylori on the ethnic distribution of esophageal eosinophilia. Helicobacter. 22(3):e12370.

Spergel J.M., Book W.M., Mays E., Song L., Shah S.S., Talley N.J., and Bonis P.A. 2011. Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States. J. Pediatr. Gastroenterol. Nutr. 52(3):300–306.

Spergel J.M., Brown-Whitehorn T.F., Beausoleil J.L., Franciosi J., Shuker M., Verma R., and Liacouras C.A. 2009. 14 years of eosinophilic esophagitis: Clinical features and prognosis. J. Pediatr. Gastroenterol. Nutr. 48:30–36.

Spergel J.M., Brown-Whitehorn T.F., Beausoleil J.L., Shuker M., and Liacouras C.A. 2007. Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis. J. Allergy Clin. Immunol. 119:509–511.

Spergel J.M., Brown-Whitehorn T.F., Cianferoni A., Shuker M., Wang M.L., Verma R., and Liacouras C.A. 2012a. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J. Allergy Clin. Immunol. 130(2):461–467.e5.

Spergel J.M., Rothenberg M.E., Collins M.H., Furuta G.T., Markowitz J.E., Fuchs G. III, O’Gorman M.A., Abonia J.P., Young J., Henkel T., Wilkins H.J., and Liacouras C.A. 2012b. Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial. J. Allergy Clin. Immunol. 129:456–463.e3.

Sperry S.L., Crockett S.D., Miller C.B., Shaheen N.J., and Dellon E.S. 2011. Esophageal foreign-body impactions: Epidemiology, time trends, and the impact of the increasing prevalence of eosinophilic esophagitis. Gastrointest. Endosc. 74(5):985–991.

Sriaroon P. and Ballow M. 2016. Biological modulators in eosinophilic diseases. Clin. Rev. Allerg. Immunol. 50:252–272.

Stein M.L., Collins M.H., Villaneuva J.M., Kushner J.P., Putnam P.E., Buckmeier B.K., Filipovich A.H., Assa’ad A.H., and Rothenberg M.E. 2006. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J. Allergy Clin. Immunol. 118(6):1312–1319.

Straumann A., Conus S., Grzonka P., Kita H., Kephart G., Bussmann C., Beglinger C., Smith D.A., Patel J., Byrne M., and Simon H.U. 2010. Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: A randomised, placebo-controlled, double-blind trial. Gut. 59:21–30.

Straumann A., Hoesli S., Bussmann C., Stuck M., Perkins M., Collins L.P., Payton M., Pettipher R., Hunter M., Steiner J., and Simon H.U. 2013. Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy. 68:375–385.

Sugnanam K.K., Collins J.T., Smith P.K., Connor F., Lewindon P., Cleghorn G., and Withers G. 2007. Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy. 62:1257–1260.

Veerappan G.R., Perry J.L., Duncan T.J., Baker T.P., Maydonovitch C., Lake J.M., Wong R.K., and Osgard E.M. 2009. Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: A prospective study. Clin. Gastroenterol. Hepatol. 7(4):420–426.e2.

von Arnim U., Wex T., Link A., Messerschmidt M., Venerito M., Miehlke S., and Malfertheiner P. 2016. Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis. Aliment. Pharmacol. Ther. 43:825–830.

Wen T., Stucke E.M., Grotjan T.M., Kemme K.A., Abonia J.P., Putnam P.E., Franciosi J.P., Garza J.M., Kaul A., King E.C., Collins M.H., Kushner J.P., and Rothenberg M.E. 2013. Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology. 145:1289–1299.